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case western reserve university

Division of Pediatric Pulmonology

 

Dearborn

 

Dorr Dearborn, M.D., Ph.D.

Professor

dxd9@case.edu
BRB Room
(216) 844-5916 Fax

 

 

Biography

After receiving his B.A. from Williamette University in 1961, Dr. Dearborn studied for his Ph.D. in Biochemistry until 1969 and his M.D. at the University of Minnesota in 1970. His Postdoc in Biochemistry was carried out at the NIH, NHLBI from 1971 to 74. Dr. Dearborn became an Assistant Professor of Biochemistry and Pediatics and Director of the Cystic Fibrosis Laboratory at Case Western Reserve University in 1974. He became Research Director of the Cleveland Cystic Fibrosis Center in 1979. In 1981 Dr. Dearborn was promoted to Associate Professor. He worked as a resident at Rainbow Babies and Childrens Hospital from 1983 to 1984. In 1996 Dr. Dearborn became Director of the Pulmonary Hemosiderosis Prevention Program at Case. He was appointed Professor in 2001. Dr. Dearborn was named Mary Ann Sears Swetland Professor and Director of The Swetland Center for Environmental Health in 2003.

Research Interests

Dearborn ’s most significant contributions to environmental health began in the fall of 1994 when he recognized an outbreak of pulmonary hemorrhage in Cleveland infants. He notified the Centers for Disease Control and Prevention (CDC) and was an integral part of the agency’s investigation, which found an association of the often-fatal disorder with toxigenic mold in the infants’ water-damaged homes. In 1996, Dearborn instituted the Pulmonary Hemosiderosis Prevention Program, a public health initiative involving the local health and housing agencies which has played a role in decreasing the incidence of the disorder.

His research program -- supported by the NIH’s National Institute of Environmental Health Sciences, the U.S. Environmental Protection Agency, and the U.S. Department of Housing and Urban Development (HUD) -- studies the effect of toxic mold on the lungs of infant animals and the impact of mold and moisture on the health of infants and young children. The latter research is performed in conjunction with the Cuyahoga County Board of Health and the Cleveland Department of Public Health. In recent years, Dearborn has published 19 papers in this area of environmental health. He frequently speaks at national and international meetings and serves on national committees, including the Healthy Homes Initiative of HUD and the Association of Occupational and Environmental Clinics.

Publications

Pestka JJ, Yike I, Dearborn DG, Ward MD, Harkema JR
"Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma"
Toxicol Sci. 2008 Jul;104(1):4-26. Epub 2007 Nov 15.

Mader DR, Yike I, Distler AM, Dearborn DG
"Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum)."
J Am Vet Med Assoc. 2007 Sep 1;231(5):731-5.

Yike I, Rand T, Dearborn DG
"The role of fungal proteinases in pathophysiology of Stachybotrys chartarum."
Mycopathologia. 2007 Oct;164(4):171-81. Epub 2007 Jul 3.

Chew GL, Wilson J, Rabito FA, Grimsley F, Iqbal S, Reponen T, Muilenberg ML, Thorne PS, Dearborn DG, Morley RL
"Mold and endotoxin levels in the aftermath of Hurricane Katrina: a pilot project of homes in New Orleans undergoing renovation"
Environ Health Perspect. 2006 Dec;114(12):1883-9.

Kercsmar CM, Dearborn DG, Schluchter M, Xue L, Kirchner HL, Sobolewski J, Greenberg SJ, Vesper SJ, Allan T
"Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources"
Environ Health Perspect. 2006 Oct;114(10):1574-80.

Vesper SJ, McKinstry C, Yang C, Haugland RA, Kercsmar CM, Yike I, Schluchter MD, Kirchner HL, Sobolewski J, Allan TM, Dearborn DG
"Specific molds associated with asthma in water-damaged homes."
J Occup Environ Med. 2006 Aug;48(8):852-8.

Yike I, Distler AM, Ziady AG, Dearborn DG
"Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum"
Environ Health Perspect. 2006 Aug;114(8):1221-6.

Yike I, Rand TG, Dearborn DG
"Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms"
Toxicol Sci. 2005 Apr;84(2):408-17. Epub 2005 Jan 12.

Yike I, Dearborn DG
"Pulmonary effects of Stachybotrys chartarum in animal studies."
Adv Appl Microbiol. 2004;55:241-73. Review.

Vesper SJ, Varma M, Wymer LJ, Dearborn DG, Sobolewski J, Haugland RA
"Quantitative polymerase chain reaction analysis of fungi in dust from homes of infants who developed idiopathic pulmonary hemorrhaging"
J Occup Environ Med. 2004 Jun;46(6):596-601

Gregory L, Pestka JJ, Dearborn DG, Rand TG
"Localization of satratoxin-G in Stachybotrys chartarum spores and spore-impacted mouse lung using immunocytochemistry"
Toxicol Pathol. 2004 Jan-Feb;32(1):26-34

Yike I, Vesper S, Tomashefski JF Jr, Dearborn DG
"Germination, viability and clearance of Stachybotrys chartarum in the lungs of infant rats"
Mycopathologia. 2003;156(2):67-75

Dearborn DG, Smith PG, Dahms BB, Allan TM, Sorenson WG, Montana E, Etzel RA
"Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland"
Pediatrics. 2002 Sep;110(3):627-37

Yike I, Miller MJ, Sorenson WG, Walenga R, Tomashefski JF Jr, Dearborn DG
"Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarum"
Mycopathologia. 2002;154(3):139-52

Tripi PA, Thomas S, Dearborn DG
"Management of general anaesthesia in infants & children with history of idiopathic pulmonary haemorrhage"
Paediatr Anaesth. 2002 Mar;12(3):243-7

Vesper SJ, Magnuson ML, Dearborn DG, Yike I, Haugland RA
"Initial characterization of the hemolysin stachylysin from Stachybotrys chartarum"
Infect Immun. 2001 Feb;69(2):912-6

Vesper S, Dearborn DG, Yike I, Allan T, Sobolewski J, Hinkley SF, Jarvis BB, Haugland RA
"Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: quantitative assessment before, during, and after remediation"
J Urban Health. 2000 Mar;77(1):68-85

Tripi PA, Modlin S, Sorenson WG, Dearborn DG
"Acute pulmonary haemorrhage in an infant during induction of general anaesthesia"
Paediatr Anaesth. 2000;10(1):92-4