Mitchell Drumm, Ph.D.
BRB Room 831
(216) 368 6893 Phone
(216) 368 4223 Fax
Dr. Drumm received his B.S. in 1983 from the Ohio State University and his Ph.D. from the University of Michigan in 1990, where he worked with Francis Collins, M.D., Ph.D., on identification of the gene causing cystic fibrosis. Dr. Drumm joined the faculty at CWRU in 1992.
My primary interests are the genetics and molecular biology surrounding the inherited disease cystic fibrosis. In particular, we are studying genes that alter the clinical course of the disease in humans, as well as using mouse models to study the physiology of the processes involved. Additionally, we are carrying out experiments to identify elements that control the activity of the CFTR gene.
Hillian AD, Londono D, Dunn JM, Goddard KA, Pace RG, Knowles MR, Drumm ML.
"Modulation of Cystic Fibrosis Lung Disease by Variants Ininterleukin-8."
Genes Immun. 2008 Jun 19 In Press.
"Construction of Chromosome Jumping and Linking Libraries in E. Coli."
Curr Protoc Hum Genet. 2001 May;Chapter 5:unit 5.4.
Hodges CA, Palmert MR, Drumm ML
"Infertility in Females with Cystic Fibrosis is Multifactorial: Evidence from Mouse Models."
Endocrinology. 2008 Jun;149(6):2790-7.
Schluchter MD, Konstan MW, Drumm ML, Yankaskas JR, Knowles MR.
"Classifying Severity of Cystic Fibrosis Lung Disease Using Longitudinal Pulmonary Function Data"
Am J Respir Crit Care Med. 2006 Jul 20
Jin R, Hodges CA, Drumm ML, Palmert MR.
"The cystic fibrosis transmembrane conductance regulator (Cftr) modulates the timing of puberty in mice"
J Med Genet. 2006 Jun;43(6):e29.
Rosenberg LA, Schluchter MD, Parlow AF, Drumm ML.
"Mouse as a model of growth retardation in cystic fibrosis"
Pediatr Res. 2006 Feb;59(2):191-5.
Drumm ML, Konstan MW, Schluchter MD, Handler A, Pace R, Zou F, Zariwala M, Fargo D, Xu A, Dunn JM, Darrah RJ, Dorfman R, Sandford AJ, Corey M, Zielenski J, Durie P, Goddard K, Yankaskas JR, Wright FA, Knowles MR; Gene Modifier Study Group.
"Genetic modifiers of lung disease in cystic fibrosis"
N Engl J Med. 2005 Oct 6;353(14):1443-53
Hart MA, Konstan MW, Darrah RJ, Schluchter MD, Storfer-Isser A, Goddard KA, Drumm ML
"Beta 2 adrenergic receptor polymorphisms in cystic fibrosis"
Pediatr Pulmonol. 2005 Jun;39(6):544-50, 2005
Davis PB, Drumm ML
"Some like it hot: curcumin and CFTR"
Trends Mol Med. 10(10):473-5, 2004
Van Heeckeren AM, Schluchter MD, Drumm ML, Davis PB
"Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice"
Am J Physiol Lung Cell Mol Physiol. 287(5):L944-52, 2004
Ulatowski LM, Whitmore KL, Romigh T, VanderWyden AS, Satinover SM, Drumm ML
"Strain-specific variants of the mouse Cftr promoter region reveal transcriptional regulatory elements"
Hum Mol Genet. 1;13(17):1933-41, 2004
"Modifier genes and variation in cystic fibrosis"
Respir Res. 2(3):125-8, 2001
Brady KG, Kelley TJ, Drumm ML
"Examining basal chloride transport using the nasal potential difference response in murine model"
Am J Physiol Lung Cell Mol Physiol. 281(5):L1173-9, 2001
Steagall WK, Drumm ML
"Stimulation of cystic fibrosis transmembrane conductance regulator-dependent short-circuit currents across DeltaF508 murine intestines"
Gastroenterology. 116(6):1379-88, 1999
Chmiel JF, Drumm ML, Konstan MW, Ferkol TW, Kercsmar CM
"Pitfall in the use of genotype analysis as the sole diagnostic criterion for cystic fibrosis"
Pediatrics. 103(4 Pt 1):823-6, 1999
Elmer HL, Brady KG, Drumm ML, Kelley TJ
"Nitric oxide-mediated regulation of transepithelial sodium and chloride transport in murine nasal epithelium"
Am J Physiol. 276(3 Pt 1):L466-73, 1999
Kelley TJ, Drumm ML
"Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells"
J Clin Invest. 102(6):1200-7, 1998